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To do Denali, you'll need more than a day or two. It's about a 3 to 4 hour trip from ANC. The trip into the park is an all day affair (well worth it, but if you are still suffering from jet lag, you'll be very tired). And then you need to travel to Seward (or possibly Whittier if on Carnival or Princess). That's about 6 hours. If you only have one or two days, go to Seward early and to the Kenai National Park day cruise.